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搜索结果

Search Results for " proprotein convertase 9 "
Targets Recommended: Others Serine/threonin kinase

14

抑制剂 & 化合物

1

天然产物

21

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T4524 SBC-110736

SBC110736

 Others; Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism; Others
SBC-110736 是一种蛋白转化酶枯草杆菌蛋白酶 9 型 (PCSK9) 抑制剂。
T2626 SBC-115076

SBC115076

 Others; Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism; Others
SBC-115076 是前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(PCSK9)抑制剂。其中PCSK9 是一种前蛋白转化酶，在 LDL 受体代谢中的重要物质。
TP1881L1 Pep 2-8 ammonium salt(1541011-97-5 free base)

Others Others
Pep 2-8 ammonium salt(1541011-97-5 free base) 是 Proprotein 转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 抑制剂。 PCSK9 与 LDL 受体结合的强效抑制剂 (IC50 = 0.8 μM)。恢复用 PCSK9 处理的 HepG2 细胞中的 LDL 摄取。
T9920 Evolocumab

Others Others
Evolocumab 是人源化单克隆抗体PCSK9的抑制剂。它与循环的 PCSK9 蛋白结合，使得PCSK9与 LDLR 结合受到抑制。它可用研究于高胆固醇血症以及动脉粥样硬化性心血管疾病的研究。
T16491 PF-06446846 hydrochloride

Others Others
PF-06446846 hydrochloride 是一种口服活性高、高选择性PCSK9(前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型)翻译抑制剂。它通过在密码子34附近诱导核糖体暂停来抑制PCSK9。
T72025 PCSK9-IN-10

Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism
PCSK9-IN-10 是一种有效的，具有口服活性的PCSK9抑制剂，IC50值为 6.4 µM。PCSK9-IN-10 增加LDLR 蛋白的表达并降低 PCSK9 的表达。PCSK9-IN-10 可减缓动脉粥样硬化进展。PCSK9-IN-10 具有研究高脂血症的潜力。
T39685 PCSK9 degrader 1

PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T70069 MDK6465

MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9). MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its name.
T13813 PCSK9 ligand 1

Others Others
PCSK9 ligand 1 is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9(Ki of 107 nM).
T78013 Pep2-8 TFA

Pep2-8是增强PCSK9拮抗活性的肽，作用于前蛋白转化酶枯草杆菌蛋白酶/可辛9型(PCSK9)。
TP1881 Pep2-8

Pep 2-8
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
T72221 PF-06815345 hydrochloride

PF-06815345 hydrochloride 是一款口服有效的PCSK9抑制剂，其IC50值为13.4 μM。在小鼠体内，能显著降低PCSK9水平。
T60541 PCSK9 modulator-2

PCSK9 modulator-2 (Compound 1) 是一种有效的PCSK9调节剂（EC50 = 202 nM）， 具有用于高脂血症的研究潜力。PCSK9 是降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。
T79051 PCSK9-IN-15

PCSK9-IN-15（化合物5）是一种高效PCSK9抑制剂，亲和力强（KD<200 nM）。该化合物与胆固醇代谢相关，可调控低密度脂蛋白胆固醇（LDL-C）水平，适用于研究降低胆固醇及血脂异常。

化合物

SBC-110736
Cat.No: T4524
Synonym: SBC110736
Target: Others, Serine/threonin kinase
SBC-115076
Cat.No: T2626
Synonym: SBC115076
Target: Others, Serine/threonin kinase
Pep 2-8 ammonium salt(1541011-97-5 free base)
Cat.No: TP1881L1
Synonym:
Target: Others
Evolocumab
Cat.No: T9920
Synonym:
Target: Others
PF-06446846 hydrochloride
Cat.No: T16491
Synonym:
Target: Others
PCSK9-IN-10
Cat.No: T72025
Synonym:
Target: Serine/threonin kinase
PCSK9 degrader 1
Cat.No: T39685
Synonym:
Target:
MDK6465
Cat.No: T70069
Synonym:
Target:
PCSK9 ligand 1
Cat.No: T13813
Synonym:
Target: Others
Pep2-8 TFA
Cat.No: T78013
Synonym:
Target:
Pep2-8
Cat.No: TP1881
Synonym: Pep 2-8
Target:
PF-06815345 hydrochloride
Cat.No: T72221
Synonym:
Target:
PCSK9 modulator-2
Cat.No: T60541
Synonym:
Target:
PCSK9-IN-15
Cat.No: T79051
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T75545 PCSK9-IN-9

PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。

天然产物

PCSK9-IN-9
Cat.No: T75545
Synonym:
Target:
Species：
Human (15)
Mouse (2)
Cynomolgus (1)
Macaca nemestrina (1)
Rat (1)
Rhesus (1)
Expression System：
HEK293 Cells (20)
P. pastoris (Yeast) (1)
Tag：
C-His (4)
C-mFc (4)
C-6xHis (3)
His (3)
C-His-Avi (2)
C-8xHis-HA-Avi (1)
C-Avi (1)
C-hFc (1)
His, Avi (1)
Tag Free (1)
Cat. No. Product Name Species Expression System
TMPY-05131 PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated

NARC-1,PC9,LDLCQ1,NARC1,FH3,proprotein

Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1.
TMPY-00408 PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)

FH3,proprotein convertase subtilisin/kexin...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1.
TMPY-04966 PCSK9 Protein, Human, Recombinant (D374Y, His)

LDLCQ1,NARC-1,PC9,NARC1,HCHOLA3,proprotein...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
TMPJ-00443 PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Proprotein Convertase Subtilisin/Kexin Typ...

 Macaca nemestrina HEK293 Cells
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
TMPY-00995 PCSK9 Protein, Rhesus, Recombinant (His)

proprotein convertase subtilisin/kexin typ...

 Rhesus HEK293 Cells
PCSK9 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.7 kDa and the accession number is A8T666.
TMPY-01565 PCSK9 Protein, Rat, Recombinant (His)

proprotein convertase subtilisin/kexin typ...

 Rat HEK293 Cells
PCSK9 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A6JYM6.
TMPJ-00368 PCSK9 Protein, Human, Recombinant (Avi), Biotinylated

Subtilisin/Kexin-Like Protease PC9,PC9,NAR...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
TMPJ-00369 PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Subtilisin/Kexin-Like Protease PC9,PCSK9,N...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7.
TMPY-05199 PCSK9 Protein, Human, Recombinant (D374Y, mFc)

PC9,proprotein convertase subtili...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05218 PCSK9 Protein, Human, Recombinant (mFc)

HCHOLA3,PC9,proprotein convertase...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1.
TMPY-05270 PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated

FH3,NARC-1,PC9,LDLCQ1,proprotein conve...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05217 PCSK9 Protein, Mouse, Recombinant (mFc)

HCHOLA3,Narc1,AI415265,AI747682,FH3,proprotein ...

 Mouse HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65.
TMPY-01245 PCSK9 Protein, Mouse, Recombinant (His)

proprotein convertase subtilisin/kexin typ...

 Mouse HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.
TMPY-05114 PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated

LDLCQ1,NARC-1,PC9,FH3,NARC1,HCHOLA3,proprotein<...

 Human HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1.
TMPK-00483 PCSK9 Protein, Cynomolgus, Recombinant (His)

PCSK9

 Cynomolgus HEK293 Cells
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His)

VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...

 Human HEK293 Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698 VEGF121b Protein, Human, Recombinant

MVCD1,VEGF,VPF,vascular endothelial growth factor A

 Human HEK293 Cells
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005 YAP1 Protein, Human, Recombinant (Isoform 9, His)

YAP1-2delta

 Human P. pastoris (Yeast)
YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPK-00825 VEGF121 Protein, Human, Recombinant (His & Avi)

VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826 VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV...

 Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268 Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

NRCAML,neurofascin,NF

 Human HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

重组蛋白

PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05131
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)
Cat.No: TMPY-00408
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, His)
Cat.No: TMPY-04966
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Macaca nemestrina, Recombinant (His)
Cat.No: TMPJ-00443
Species: Macaca nemestrina
Expression System: HEK293 Cells
PCSK9 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-00995
Species: Rhesus
Expression System: HEK293 Cells
PCSK9 Protein, Rat, Recombinant (His)
Cat.No: TMPY-01565
Species: Rat
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated
Cat.No: TMPJ-00368
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated
Cat.No: TMPJ-00369
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc)
Cat.No: TMPY-05199
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-05218
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated
Cat.No: TMPY-05270
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (mFc)
Cat.No: TMPY-05217
Species: Mouse
Expression System: HEK293 Cells
PCSK9 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01245
Species: Mouse
Expression System: HEK293 Cells
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated
Cat.No: TMPY-05114
Species: Human
Expression System: HEK293 Cells
PCSK9 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00483
Species: Cynomolgus
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00865
Species: Human
Expression System: HEK293 Cells
VEGF121b Protein, Human, Recombinant
Cat.No: TMPY-03698
Species: Human
Expression System: HEK293 Cells
YAP1 Protein, Human, Recombinant (Isoform 9, His)
Cat.No: TMPH-00005
Species: Human
Expression System: P. pastoris (Yeast)
VEGF121 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00825
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00826
Species: Human
Expression System: HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05268
Species: Human
Expression System: HEK293 Cells
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